xQTL Data Portal

Harmonized multi-omic
brain xQTLs

Investigate GWAS hits, genes, and genomic regions across integrated brain datasets from ROSMAP, MSBB, Knight-ADRC, and more.

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Integrated brain xQTLs from ROSMAP, MSBB, Knight-ADRC, and more

Examples

14 Brain regions

7 Cell types

6 Omics types

13,000+ Samples

300M+ xQTL associations

Show abbreviations and term definitions

Brain regions

DLPFC: Dorsolateral prefrontal cortex
FC_BA_10: Frontal cortex Brodmann Area 10
FC_BA_22: Frontal cortex Brodmann Area 22
FC_BA_36: Frontal cortex Brodmann Area 36
FC_BA_44: Frontal cortex Brodmann Area 44
PC: Parietal cortex
PCC: Posterior cingulate cortex
PHG: Parahippocampal gyrus
AC: Anterior caudate

Cell types

exc: Excitatory neuron
inh: Inhibitory neuron
mic: Microglia
mon: Monocyte
oli: Oligodendrocyte
opc: Oligodendrocyte progenitor cell
ast: Astrocyte

Cohorts / studies

Knight-ADRC: Knight Alzheimer's Disease Research Center
MSBB: Mount Sinai Brain Bank
MiGA: Microglia Genomic Atlas
ROSMAP: Religious Orders Study / Memory and Aging Project
ROSMAP_snuc_DeJager: ROSMAP single-nucleus, DeJager lab
ROSMAP_snuc_Kellis: ROSMAP single-nucleus, Kellis lab
ROSMAP_snuc_mega: ROSMAP single-nucleus mega-analysis

xQTL types

eQTL: Expression QTL
haQTL: Histone accessibility QTL
mQTL: Methylation QTL
pQTL: Protein QTL
sQTL: Splicing QTL
snuc-eQTL: Single-nucleus expression QTL