Quantitative trait loci (QTLs) describe associations between genetic variants and molecular traits. This Atlas uses data from the ROSMAP, MSBB, Knight-ADRC, and MiGA resources to make harmonized xQTL and fine-mapping results accessible across fourteen brain regions and seven cell types (see About and Methods). Molecular traits represented in the Atlas include single-nucleus and bulk gene expression, protein abundance, histone acetylation, DNA methylation, and splicing events.
Select one of the example queries below, or enter your own query and click Search. View results in the genome browser or download TSV files for downstream analysis.
Distribution of xQTL associations across cell and tissue contexts.
Search for brain xQTLs and fine-mapping associations by genomic position, region, variant, or target gene.
Searches cover 83 million HMT-significant xQTLs and fine-mapped 95% credible-set associations identified from more than 25 billion tested brain xQTLs.
Find information about output formats, abbreviations, data sources, interpretation guidance, and other details about the Atlas.
Explore xQTL significance at a region of interest. Search by genomic position or gene symbol and select the tracks to display.
Fine-mapping tracks will be added soon.
Download TSV files containing significant associations by variant, target gene, or genomic region.
See file formats and metadata for complete format descriptions.