Quantitative trait loci (QTLs) describe associations between genetic variants and molecular traits. This Atlas uses data from the ROSMAP, MSBB, Knight-ADRC, and MiGA resources to make harmonized xQTL and fine-mapping results accessible across fourteen brain regions and seven cell types (see About and Methods). Molecular traits represented in the Atlas include single-nucleus and bulk gene expression, protein abundance, histone acetylation, DNA methylation, and splicing events. Read more...
Select one of the example queries below, or enter your own query and click Search.
View results in the genome browser or download TSV files for downstream analysis.
The Alzheimer's Disease Sequencing Project (ADSP) is a consortium of National Institute on Aging (NIA)-funded consortia studying the genetic underpinnings of Alzheimer's disease (AD) and AD-related dementias (ADRD) to improve the prevention and treatment of these diseases.
The ADSP Functional Genomics Consortium xQTL working group (FunGen-xQTL) was established to generate a harmonized, brain-centric resource for this task. The FunGen-xQTL Atlas is a next-generation human brain xQTL resource spanning histone acetylation, DNA methylation, gene expression, splicing and protein abundance QTLs across fourteen brain regions and seven cell types from four large postmortem brain studies, including the Religious Orders Study and Memory and Aging Project (ROSMAP), Mount Sinai Brain Bank (MSBB), Charles F. and Joanne Knight Alzheimer's Disease Research Center (Knight-ADRC), and Microglia Genomic Atlas (MiGA).
This xQTL Atlas provides researchers freely accessible functional annotations of variants, genes, and genomic regions from various brain contexts. These annotations can be interactively searched, viewed via a genome browser or a number of generated plots, and downloaded for downstream analyses. All data powering this resource is available via the NIAGADS DSS Open Access Data Portal
Read our manuscript on medRxiv: DOI: 10.64898/2026.05.21.26353713
Use the Home/Search page to search for brain xQTLs and fine-mapping associations by their genomic position via variant and region search, or by searching for the genes they target. These searches are conducted for 83 million HMT-significant xQTLs and for fine-mapped 95% credible set associations, identified from over 25 billion tested brain xQTLs.
Visit the About page for extensive information on output formats, abbreviation explanations, source information, interpretation tips, and more.
Use the View in Genome Browser tab to see the significance of xQTLs at your region of interest. Search by genomic position or gene symbol, and specify the tracks you want to include. Viewing of fine-mapping results here is coming soon!
Use the Download tab to get TSVs. Full format explanations are available on the About page here.
For additional information on each portal functionality, see the Tutorials and How-To section of the About.
We would love to hear from you! Reach out to us via help@niagads.org.
Current release: v1.0, June 18, 2026. Data and annotations will be updated in future releases.
Full xQTL data/all tested associations are available through NIAGADS DSS (NG00184).
Last updated: July 20, 2026 19:50:40