Quantitative trait loci (QTLs) describe associations between genetic variants and molecular traits. This Atlas uses data from the ROSMAP, MSBB, Knight-ADRC, and MiGA resources to make harmonized xQTL and fine-mapping results accessible across fourteen brain regions and seven cell types (see About and Methods). Molecular traits represented in the Atlas include single-nucleus and bulk gene expression, protein abundance, histone acetylation, DNA methylation, and splicing events.
Select one of the example queries below, or enter your own query and click Search. View results in the genome browser or download TSV files for downstream analysis.
Use the Home/Search page to search for brain xQTLs and fine-mapping associations by their genomic position via variant and region search, or by searching for the genes they target. These searches are conducted for 83 million HMT-significant xQTLs and for fine-mapped 95% credible set associations, identified from over 25 billion tested brain xQTLs.
Visit the About page for extensive information on output formats, abbreviation explanations, source information, interpretation tips, and more.
Use the View in Genome Browser tab to see the significance of xQTLs at your region of interest. Search by genomic position or gene symbol, and specify the tracks you want to include. Viewing of fine-mapping results here is coming soon!
Use the Download tab to get TSVs. Full format explanations are available on the About page here.
We would love to hear from you! Reach out to us via help@niagads.org.
Current release: v1.0, June 18, 2026. Data and annotations will be updated in future releases.
Full xQTL data/all tested associations are available through NIAGADS DSS (NG00184).
Last updated: August 04, 2026 12:53:33