Explore harmonized brain xQTL associations spanning histone acetylation, DNA methylation, gene expression, splicing and protein abundance QTLs across
fourteen brain regions and seven cell types.
Search by GWAS hit, variant, gene, or genomic region to examine regulatory effects across cohorts, brain regions, cell types, and molecular data types.
The portal integrates
ROSMAP, MSBB, Knight-ADRC, and MiGA,
to help link genetic variation to functional molecular mechanisms. Read more...
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Integrated brain xQTLs from ROSMAP, MSBB, Knight-ADRC, and more
Examples
14Brain regions
7Cell types
6Omics types
17,000+Samples
300M+xQTL associations
Show abbreviations and term definitions
Brain regions
DLPFC
Dorsolateral prefrontal cortex
FC_BA_10
Frontal cortex Brodmann Area 10
FC_BA_22
Frontal cortex Brodmann Area 22
FC_BA_36
Frontal cortex Brodmann Area 36
FC_BA_44
Frontal cortex Brodmann Area 44
PC
Parietal cortex
PCC
Posterior cingulate cortex
PHG
Parahippocampal gyrus
AC
Anterior caudate
Cell types
exc
Excitatory neuron
inh
Inhibitory neuron
mic
Microglia
mon
Monocyte
oli
Oligodendrocyte
opc
Oligodendrocyte progenitor cell
ast
Astrocyte
Cohorts / studies
Knight-ADRC
Knight Alzheimer's Disease Research Center
MSBB
Mount Sinai Brain Bank
MiGA
Microglia Genomic Atlas
ROSMAP
Religious Orders Study / Memory and Aging Project
ROSMAP_snuc_DeJager
ROSMAP single-nucleus, DeJager lab
ROSMAP_snuc_Kellis
ROSMAP single-nucleus, Kellis lab
ROSMAP_snuc_mega
ROSMAP single-nucleus mega-analysis
xQTL types
eQTL
Expression QTL
haQTL
Histone acetylation QTL
mQTL
Methylation QTL
pQTL
Protein QTL
sQTL
Splicing QTL
snuc-eQTL
Single-nucleus expression QTL
Getting Started
To get started, click on the Home/Search to search by variant rsID, gene name, or genomic coordinates.
Or click Genome Browser to explore xQTL data for candidate loci or gene of interest.
See Download to download xQTL association for individual variants, genes, or genomic regions.
See About for overview of the portal, data in the portal, data harmonization, and how-tos.
See Methods for detail of data processing and xQTL pipeline(s).
Release info
Current release: v1.0, June 18, 2026 Data and annotations will be updated in future releases.
Full xQTL data/all tested associations are available through NIAGADS DSS (NG00184).